Champions Asante Kotoko will look to record their first win in the 2014/2015 First Capital Plus Premier League season when they take on Hasaacas in Kumasi.
Hasaacas who are leading the league table after their 3-1 victory over Liberty Professionals will however expect to leave the Babayara stadium with a positive result having started the league on a positive note.
Matches at the other league centres promises to be exciting with Berekum Chelsea will welcoming Hearts of Oak at their adopted-home, Essipong Stadium.
Chelsea, just like Hearts of Oak, are facing a home ban and will hope to beat the Phobians after losing their first match of the season against Wa Allstars.
Allstars after their home win will go away to Tarkwa as guests to Medeama SC with the home-side expecting to put their defeat on Match-day behind them and return to winning ways.
Great Olympics will hope to appease their home fans after a disappointing start to the season which saw them mark their return to topflight football with a 2-0 away loss to AshantiGold.
At the Dansoman Stadium, Liberty Professionals who were the only side to score an away goal on the opening day of the season, will hope to improve their performance this time around when they take on B.A. United.
B.A. United who are returning into the Ghanaian Premier League after their long absence, lost their maiden game of the season in the Brong Ahafo derby against Bechem United.
WAFA who will be playing their first Premier League match at the Sogakope park against, will face another tough opposition when they play at home against Ashantigold. Formerly known as Feyenoord Academy, WAFA announced their return to the topflight with an away defeat to Accra Hearts of Oak in Kpando.
And to wrap up the fixtures for the match day two, Bechem United and Inter Allies who both won their first matches of the season will battle at the Bechem park as they both hope to maintain their positive start to the season.