Atalanta forward Richmond Boakye Yiadom and David Accam have been invited to join the Black Stars camp in France.
The duo will replace injured Baba Rahman and Mahatma Otoo who have been ruled out of the friendlies against Senegal and Mali towards the end of the month.
Coach Avram Grant and his 22-man team will begin camping in Paris this week ahead of the friendlies which will be played on March 28 and 31st respectively.
Updated Ghana squad
Goalkeepers: Razak Braimah (Mirandes, Spain), Fatau Dauda (AshGold)
Defenders: Harrison Afful (Esperance, Tunisia), John Boye (Erciyesspor, Turkey), Jonathan Mensah (Evian, France), Jeffery Schlupp (Leicester City, England), Gyimah Edwin (Mpumalanga Black Aces, South Africa), Daniel Amartey, (FC Copenhagen, Denmark)
Midfielders: Rabiu Mohammed (Krasnodar, Russia), Emmanuel Agyemang-Badu (Udinese, Italy), Afriyie Acquah (Sampdoria, Italy), Solomon Asante (T.P. Mazembe, DR Congo), Christian Atsu (Everton, England), Mubarak Wakaso (Celtic, Scotland), Andre Ayew (Olympique Marseille, France), Frank Acheampong (Anderlecht, Belgium), Seidu Salifu (Club Africaine, Tunisia)
Forwards: Jordan Ayew (Lorient, France), Kwesi Appiah (Crystal Palace, England), Richmond Boakye-Yiadom (Atalanta, Italy), David Accam (Chicago Fire, U.S.A)